咨詢問題我要詳細了解該課題 -
對醛基苯甲酸進行酰氯化反應時醛基需要保護嗎？
對醛基苯苯甲酸與氯化亞砜反應時，醛基會不會也與氯化亞砜發生副反應，或對醛基苯苯甲酸與反應生成的對醛基苯甲酰氯反應生產副產物？指老師批教！
咨詢者：劉先生 咨詢時間：2011-01-07 狀態：已回復
專家 解答表達感謝 繼續咨詢該問題 參與討論-
不必保護(1) Commercially available 4-formylbenzoic acid (5.0 g, 33.3 mmol) was dissolved in a mixture of anhydrous tetrahydrofuran (100 ml) and anhydrous N,N-dimethylformamide (1 ml) and the mixture was cooled with stirring to 0.degree. C. To the resulting mixture was added dropwise oxalyl chloride (3.8 ml, 43.3 mmol). The mixture was stirred at room temperature for 30 minutes and then at 40.degree. C. for 20 minutes. The reaction mixture was concentrated under reduced pressure and then in vacuo to afford 4-formylbenzoyl chloride.
2）有問題，請來電：13651797090老張
回復： 回復時間：2011-01-09
留言 11-01-09 12:09 發布者:laozhang回復 參與討論-
(1) Commercially available 4-formylbenzoic acid (5.0 g, 33.3 mmol) was dissolved in a mixture of anhydrous tetrahydrofuran (100 ml) and anhydrous N,N-dimethylformamide (1 ml) and the mixture was cooled with stirring to 0.degree. C. To the resulting mixture was added dropwise oxalyl chloride (3.8 ml, 43.3 mmol). The mixture was stirred at room temperature for 30 minutes and then at 40.degree. C. for 20 minutes. The reaction mixture was concentrated under reduced pressure and then in vacuo to afford 4-formylbenzoyl chloride.
如有問題，請來電 13651797090
- 留言 11-01-09 12:37 發布者:老張回復 參與討論
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不必保護，參考usp7,572,790
4-Bromo-3-formylbenzoyl chloride
Intermediate 28 (886 mg) and thionyl chloride (4 ml) were heated at reflux under nitrogen for 1 hr. The excess thionyl chloride was evaporated in vacuo and the residue azeotroped with toluene (5 ml.times.3) to give 4bromo-3-formylbenzoyl chloride as a yellow/white solid.
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